THERAPEUTIC INDICATIONS
Joint diseases accompanied by pain syndrome caused by degenerative or post-traumatic conditions or changes in the joints. This product allows to restore the optimal rheological and physiological conditions for the functioning of joints due to its viscoelastic and lubricating properties. By improving the characteristics of synovial fluid, the product provides protection for the joints. These properties help improve joint function and reduce joint pain.
RECOMMENDATIONS FOR USE
The product should be administered by intra-articular injections, using a sterile 20G needle. Intra-articular injection should be performed by a qualified doctor, according to the technical and aseptic requirements that must be observed for this method of administration. Due to the viscosity of the solution, the needle should be tightly threaded onto the luer tip of the syringe barrel to ensure a tight seal and prevent leakage of solution between the needle and syringe during the product administration.
DOSAGE
Generally, unless otherwise recommended by the doctor: perform one intra-articular injection with 2.0 ml of the product (40 mg polynucleotide), once a week for 3-6 weeks.
CONTRAINDICATIONS
The use of CHRONOTRON® is contraindicated in patients with hypersensitivity to any of the product components, or with a history of allergic reactions to the use of products derived from fish tissue. To prevent the development of bacterial arthritis, the product should not be injected into joints with signs of infection or pronounced inflammation, or in cases where the patient has an ongoing infection localized in the immediate vicinity of the injection site. The efficacy and safety of CHRONOTRON® have not been established in pregnant women, breastfeeding women and children.
SIDE EFFECTS
During use of CHRONOTRON® some adverse effects associated with the clinical practice of intra-articular injections may occur, including localized pain, fever, redness, and swelling. These symptoms can be treated by resting the joint and applying ice to the joint and are usually resolved within a short period of time. If symptoms persist, consult a doctor. Doctors should advise patients to inform them of any adverse events that may develop after treatment.
PRECAUTIONS FOR USE
The product is intended for single use. The product should be used with special caution in case of congestion in the lymphatic or venous system of the lower limb to be treated. It is recommended to eliminate any signs of joint swelling (if any), before the product is administered. Patients receiving intra-articular injections should avoid strenuous physical activity that could damage the joint, and resume standard activity after several days. The product should not be used together with disinfectants containing quaternary ammonium salts or chlorhexidine. The product should not be injected intravascularly, periarticularly, into the synovial membrane, or into the joint capsule. The product should not be injected if there are impurities in the syringe.
SPECIAL WARNINGS
Intra-articular injections should only be performed by healthcare professionals. Before using the syringe, make sure that the package is completely sealed: do not use if the sterile package is damaged or has already been opened. Do not use the product after the expiration date printed on the package. The expiration date refers to the unopened product if stored properly. Use the product immediately after opening and dispose of it after use. The product should only be distributed by prescription.