The use of intra-articular forms of hyaluronic acid in degenerative-dystrophic and post-traumatic joint lesions is a well-studied method with an established safety profile that has been used for several decades. In extremely rare cases, local temporary inflammatory symptoms may occur (pain, fever, redness and swelling, an increase in the content of exudate in the joint cavity). After an intra-articular injection, reversible local reactions such as short-term limitation of mobility (stiffness), discomfort or heaviness in the joint, hematomas may occur. The signs of these symptoms can be reduced by applying ice to the injection site for 5-10 minutes. There are reports of single cases of allergic reactions (eg, itching, rash, urticaria) and anaphylactic reactions, septic arthritis, interstitial bleeding or hemorrhage in the joint cavity, tendinitis, phlebitis, paresthesia, dizziness, headaches, muscle cramps, feeling hot, general malaise, peripheral edema with intra-articular injection of hyaluronic acid solutions. If you experience local or general symptoms, you should consult your doctor.